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Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that affects multiple tissues and organs throughout the body, characterized by the immune system mistakenly attacking its own tissues. The disease may involve the skin, joints, kidneys, blood system, cardiovascular system, and nervous system, with diverse symptoms and significant individual differences. It is more common in young women but not exclusive to them, as it can occur in all ages and genders. The course is often fluctuating, with pronounced symptoms during flare-ups and relative stability during remission. Treatment aims to control inflammation, relieve symptoms, and delay organ damage.
1. Europe and North America
In Europe and North America, the diagnosis and treatment system for systemic lupus erythematosus is relatively well established, with high early screening rates. Epidemiological surveys in the U.S. and Canada show that the incidence in women is significantly higher than in men. With superior medical conditions, patient survival has improved, though quality of life remains affected. Long-term management and medication are crucial for disease control.
2. Southeast Asia
The incidence of systemic lupus erythematosus in Southeast Asia is increasing year by year, particularly among urban populations. Climate, diet, and environmental factors may contribute to disease development. In recent years, with improved healthcare, local hospitals have enhanced diagnostic and treatment capabilities, but due to uneven distribution of medical resources in some regions, patients still face delayed diagnosis and insufficient treatment.
1. Organ damage and functional decline
SLE can affect multiple organs, with kidney involvement being the most common and potentially leading to renal failure. Inflammation or immune-mediated damage to the heart, lungs, and central nervous system also impacts patients’ quality of life and life expectancy. Without timely treatment, severe complications may develop.
2. Decline in quality of life
Patients face not only long-term medication side effects but also pain, fatigue, and other symptoms from repeated flare-ups. The unpredictability of the disease often causes anxiety and depression, leading to long-term impacts on work, study, social life, family relationships, and finances.
Immune reconstruction cell therapy has gained attention in recent years in the field of autoimmune diseases. By reinfusing healthy, active immune cells, it helps patients restore immune balance and reduce immune attacks on their own tissues. Its key advantage lies not only in alleviating symptoms but also in potentially slowing disease progression, creating conditions for long-term remission.
1. Enhancing immune system regulation
Reinfused healthy immune cells can correct immune dysfunction in patients and reduce abnormal immune responses.
2. Reducing drug dependence
In some patients, cell therapy can reduce the frequency of using corticosteroids and immunosuppressants, thereby lowering risks of long-term side effects.
3. Slowing organ damage
By improving immune balance and reducing inflammatory responses, this therapy may slow damage to vital organs such as the kidneys and heart, extending stability for patients.
During traditional treatments, patients often experience immune dysfunction, increased infection risk, and slow recovery. To better support them, improve tolerance, and enhance quality of life, scientifically designed phased immune reconstruction plans tailored to different treatment cycles are needed.
● Short-term plan: Quickly boost immunity through immune cell reinfusion to enhance anti-disease effectiveness.
● Mid-term plan: Reduce side effects of traditional treatments, promote recovery, and ensure completion of standardized regimens.
● Long-term plan: Gradually strengthen immunity through immune cell reconstruction, gut immune reconstruction, elemental immune reconstruction, and immune nutrition reconstruction, ultimately improving quality of life and extending survival.
1. Glucocorticoid therapy
Commonly used to control acute inflammation, it can rapidly relieve symptoms, but long-term use requires caution regarding side effects such as osteoporosis and metabolic abnormalities.
2. Immunosuppressants
Drugs such as cyclophosphamide and azathioprine are used to suppress overactive immune responses and reduce inflammatory damage.
3. Antimalarials
Drugs like hydroxychloroquine can relieve skin and joint symptoms and help reduce disease recurrence rates.
4. Biologics
Biologics targeting B cells or related inflammatory factors offer new options for patients unresponsive to traditional medications.
5. Symptomatic and supportive treatment
Personalized supportive care is provided for complications such as anemia, hypertension, and renal dysfunction, aiming to improve overall health.
Systemic lupus erythematosus is a complex autoimmune disease with widespread impact. Without timely treatment, it can lead to irreversible organ damage. Experts at United Life International Medical Center emphasize that scientific diagnosis, comprehensive treatment, and long-term management are key to maintaining patients’ health and quality of life. The combination of emerging immune reconstruction cell therapy with traditional approaches may bring new survival opportunities for more patients.
