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Penile cancer mainly occurs on the foreskin, glans, or shaft of the penis. It is a rare but clinically concerning male malignancy. Most cases occur in middle-aged and elderly men, though younger patients are not excluded. The disease progresses relatively slowly, but if not detected early, it can easily lead to local invasion and distant metastasis. The medical community is continuously advancing diagnostic and treatment methods, particularly by integrating precision therapy and immune interventions, to improve treatment outcomes and quality of life.
Penile cancer is rare worldwide. In the United States, Europe, and other resource-rich countries, it is uncommon, accounting for less than 1% of male cancers in the U.S., with over 2,000 new cases and about 500 deaths annually.
However, in resource-limited regions, penile cancer is more common. In parts of Africa, Asia, South America, and developing countries such as India, Brazil, and Southeast Asia, factors such as poor hygiene, phimosis, and HPV infection contribute to higher incidence. Many countries are strengthening men’s health education and early screening. In some regions, penile cancer accounts for 10%–20% of all male malignancies.
It is a typical disease of older age, with incidence increasing with age. The average age of diagnosis is 60, though cases under 40 also exist.
1. Impact on reproductive system function
Penile cancer is highly destructive to local tissues, and when advanced, it often invades deep into the penile shaft, causing sexual dysfunction and urinary difficulties, severely affecting quality of life.
2. Severe psychological burden
Patients often experience loss of self-esteem, sexual anxiety, and psychological distress. Without timely intervention, depression, social withdrawal, and poor treatment compliance may develop.
3. Risk of metastasis
Penile cancer can spread via the lymphatic system to the inguinal lymph nodes, and without early intervention, may metastasize further to distant organs, increasing treatment difficulty and worsening prognosis.
4. Significant lifestyle limitations
Some patients undergoing surgery or radiotherapy may face urinary reconstruction or local functional impairment, limiting daily activities and requiring long-term rehabilitation and follow-up care.
Immune reconstruction cell therapy enhances and reshapes the patient’s immune system, improving the ability of immune cells to identify and eliminate cancer cells. This provides a new direction for penile cancer treatment. It can be used alongside surgery, radiotherapy, chemotherapy, or minimally invasive techniques to enhance comprehensive anti-cancer effects, reduce recurrence risk, and provide benefits for patients with local recurrence or metastasis.
During actual treatment, penile cancer patients often face immune dysfunction, higher infection risk, and slow recovery due to surgery, radiotherapy, and chemotherapy. To help patients better withstand treatment, improve tolerance, and enhance quality of life, phased immune reconstruction plans tailored to different treatment cycles should be scientifically designed.
● Short-term plan: Rapidly enhance immunity through immune cell reinfusion to boost the effectiveness of anti-tumor treatment.
● Mid-term plan: Reduce side effects of traditional treatments, promote physical recovery, and complete standardized treatment courses.
● Long-term plan: Improve overall immunity through immune cell reconstruction, gut immune reconstruction, elemental immune reconstruction, and immune nutrition reconstruction, thereby enhancing quality of life and prolonging survival.
1. Local excision and penile-preserving surgery
Early-stage lesions can often be treated with local tumor excision or penile-preserving surgery to maintain organ function and appearance as much as possible. Close follow-up is required postoperatively to monitor for recurrence, making this a commonly used treatment strategy.
2. Lymph node dissection
If inguinal lymph node metastasis is found, lymph node dissection may be considered. This helps control cancer spread and is especially important for patients with advanced disease.
3. Radiotherapy
For patients unsuitable for surgery or requiring postoperative adjuvant therapy, external beam radiotherapy or brachytherapy can be selected. This method effectively controls local lesion progression and is applicable to different stages of disease.
4. Minimally invasive treatment methods
In recent years, some early cases have attempted minimally invasive approaches such as laser excision, cryotherapy, or photodynamic therapy. These treatments are less traumatic and allow faster recovery, particularly suitable for patients with high functional requirements, though indications must be strictly controlled at present.
Although penile cancer has a low incidence rate, it has a significant impact on both physical and psychological health. Various treatment methods can be combined to achieve optimal disease control. Experts at United Life International Medical Center emphasize that standardized screening and personalized treatment are key to reducing its harm.
