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Malignant tumors of the oral cavity are mainly squamous cell carcinomas, with minor salivary gland carcinomas and sarcomas being less common. Oral cancer can involve the following anatomical sites: lips, lower alveolar ridge, upper alveolar ridge, retromolar trigone (retromolar gingiva), hard palate, anterior two-thirds of the tongue, floor of the mouth, and buccal mucosa.
In Western countries, smoking and alcohol consumption are the primary risk factors for oral squamous cell carcinoma. In Asia and India, betel nut chewing is an important factor. Oral tobacco, periodontal disease, radiation, and diseases of immune deficiency or dysregulation are also associated with oral cancer. Carcinogenic HPV infection (especially HPV-16) is related to an increased incidence of tonsil and base-of-tongue cancers. However, the proportion of oral cancers associated with HPV infection is significantly lower, with most p16-positive oral cancers being HPV-negative unless originating near the contour papilla.
The 5-year survival rate for stage I or II oral cancer is 70%. For locally advanced oral cancer and oropharyngeal cancer, the 5-year relative survival rate is 54.7%. Generally, the first 2–4 years of follow-up are the most intensive, as about 80–90% of recurrences occur during this period.
The incidence of oral cancer varies significantly worldwide. In 2020, there were approximately 378,000 cases of oral cancer globally, causing about 178,000 deaths. The incidence is higher in parts of Asia and Africa, particularly India, Pakistan, and some Southeast Asian countries, all showing an upward trend. In Western countries, incidence is relatively lower due to lifestyle differences and the widespread adoption of early screening.
1. Strong Local Destructiveness
Oral cancer is highly invasive and easily destroys intraoral structures, leading to dysfunctions such as difficulties in chewing, swallowing, and speaking, severely affecting patients’ quality of life.
2. High Risk of Metastasis
This cancer type often spreads through the lymphatic system to cervical lymph nodes and can metastasize to distant organs in advanced stages, increasing treatment difficulty and mortality risk.
3. Heavy Psychological Burden
Oral cancer patients often experience significant psychological stress due to changes in oral appearance and functional impairment, leading to anxiety and depression, which affect treatment compliance and recovery outcomes.
Immune reconstruction cell therapy, as a breakthrough in oral cancer treatment, aims to enhance the patient’s immune system in recognizing and eliminating cancer cells. The advantages of this therapy include:
① Activating immune cells within the body;
② Inhibiting tumor growth and metastasis;
③ Reducing side effects of traditional therapies and improving quality of life. This method has become an important component of oral cancer treatment at the United Life International Medical Center.
In clinical practice, since cancer patients often face impaired immune function, increased infection risk, and slow recovery during surgery, radiotherapy, and chemotherapy, it is necessary to formulate phased immune reconstruction plans for different treatment cycles to help patients better withstand treatment, improve tolerance, and enhance survival quality.
● Short-term Plan: Rapidly enhance immunity through immune cell reinfusion, boosting the effectiveness of anti-cancer treatment.
● Mid-term Plan: Reduce side effects of traditional treatments, promote physical recovery, and complete standardized treatment courses.
● Long-term Plan: Enhance overall immunity through immune cell reconstruction, gut immune reconstruction, elemental immune reconstruction, and immune nutrition reconstruction, thereby improving quality of life and extending survival.
1. Surgical Treatment
Surgical resection remains the fundamental treatment for oral cancer, suitable for early-stage patients. Modern minimally invasive techniques, such as endoscope-assisted surgery, allow more precise excision, faster recovery, and reduced complications.
2. Radiotherapy
Radiotherapy uses high-energy rays to kill cancer cells and is a key option for patients who cannot undergo surgery or as adjuvant therapy. Modern precision radiotherapy techniques can maximize protection of surrounding normal tissues.
3. Chemotherapy
Chemotherapy is often combined with radiotherapy for synergistic effects to improve efficacy, mainly applicable to advanced or recurrent cases.
4. Minimally Invasive Treatments
Minimally invasive techniques include laser therapy, cryotherapy, and endoscopic tumor resection, suitable for early localized lesions. These approaches cause less trauma, allow faster recovery, and are appropriate for patients with weaker constitutions.
Due to its strong invasiveness and high risk of metastasis, oral cancer requires timely diagnosis and treatment. Experts from United Life International Medical Center emphasize that combining immune reconstruction cell therapy with traditional surgery, radiotherapy, and chemotherapy can significantly improve patient outcomes and quality of life. They also call on the public to pay attention to early screening and standardized treatment.
