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Treatment of systemic sclerosis mainly focuses on immunosuppression and anti-fibrosis, aiming to slow disease progression and control symptoms. Combining traditional drugs with emerging immune cell therapies, multidisciplinary collaboration, and individualized treatment strategies have gradually become mainstream, helping patients achieve better therapeutic outcomes and quality of life.
Europe and America
In Europe and America, the incidence of systemic sclerosis is relatively high, with more female patients, about 20 to 40 cases per 100,000 people. The medical systems in these regions emphasize early diagnosis and comprehensive treatment. Clinical research is active, and patients generally receive good disease management and follow-up support.
Southeast Asia
The incidence in Southeast Asia is lower, about 5 to 15 cases per 100,000 people. Patients often have more severe internal organ involvement. Uneven distribution of medical resources leads to delays in diagnosis and treatment in some areas. With the improvement of healthcare levels, awareness of early screening and treatment has gradually increased, improving patient prognosis.
Immune reconstruction cell therapy regulates abnormal immune responses, promotes fibrosis reversal and tissue repair, bringing new treatment hope to patients with systemic sclerosis. This therapy enhances immune balance, reduces the side effects of traditional treatments, and significantly improves patient survival quality and treatment tolerance.
1. Precise immune regulation
Cell therapy can precisely regulate abnormal immune cells, effectively reducing inflammation and fibrosis progression, promoting tissue repair, and improving organ function and quality of life.
2. Reduced drug side effects
Cell therapy reduces reliance on immunosuppressants, significantly lowering side effects caused by traditional drugs and improving overall treatment tolerance and compliance.
3. Promoting immune system reconstruction
Cell therapy helps rebuild the immune system, enhances resistance to infections, improves quality of life, extends survival, and promotes functional recovery.
In actual treatment, traditional regimens often lead to immune dysfunction, increased infection risk, and slow recovery. To help patients better tolerate treatment, improve endurance, and enhance quality of life, phased immune reconstruction programs must be scientifically developed for different cycles.
● Short-term plan: Rapidly enhance immunity through immune cell reinfusion to strengthen treatment effects.
● Mid-term plan: Reduce side effects of conventional treatments, promote recovery, and ensure completion of standardized regimens.
● Long-term plan: Comprehensive improvement of immunity through immune cell reconstruction, gut immunity restoration, elemental immunity rebuilding, and immune nutrition support, thereby improving quality of life and prolonging survival.
1. Immunosuppressive therapy
Immunosuppressants such as cyclophosphamide and methotrexate effectively control immune responses, slow fibrosis progression, and are commonly used in systemic sclerosis, under physician supervision.
2. Calcium channel blockers
Used to treat Raynaud’s phenomenon, improve vascular contraction and blood flow disorders, relieve ischemic symptoms of extremities, and improve patient comfort.
3. Anti-fibrosis drugs
Such as pirfenidone and nintedanib, which inhibit fibroblast activity, slow fibrosis progression in the lungs and other tissues, and delay organ function deterioration.
4. Proton pump inhibitors
Used to control gastroesophageal reflux and esophagitis, protect esophageal mucosa, relieve digestive symptoms, and improve nutritional status.
5. Vasodilators
Such as prostaglandin analogs, improve microcirculation, promote angiogenesis, relieve skin hardening and blood flow disorders, and improve limb function.
6. Pulmonary hypertension treatment
For pulmonary hypertension complications, endothelin receptor antagonists and phosphodiesterase-5 inhibitors improve cardiopulmonary function and extend survival.
7. Physical therapy
Rehabilitation measures such as functional training, massage, and hot compresses help relieve joint contractures and muscle hardening, promoting limb function recovery.
8. Psychological support and care
Patients with systemic sclerosis often experience psychological stress. Comprehensive psychological support and nursing interventions help improve psychological state, treatment compliance, and quality of life.
Systemic sclerosis leads to multi-organ damage due to immune abnormalities and fibrosis, severely affecting patients’ lives and health. Timely standardized treatment is key to controlling disease progression. Experts at United Life International Medical Center point out that combining stem cell immune reconstruction with traditional treatments can effectively improve prognosis and quality of life, and is worth widespread adoption.
