Considering both high-income and low-income countries, uterine cancer is the second most common gynecological cancer worldwide, second only to cervical cancer. More than 90% of uterine cancers are endometrial carcinomas (EC), originating from the epithelium; the rest are mostly mesenchymal cancers originating from the myometrium, with a few being endometrial stromal sarcomas.
The incidence of endometrial carcinoma (EC) among American women is about 3%, making it the fourth most common cancer in women in the United States, following breast cancer, lung/bronchial cancer, and colorectal cancer. The peak incidence occurs at ages 60–70, but 2%–5% of cases occur before the age of 40. For patients around the age of 50, risk factors often include prolonged anovulation and/or obesity, or genetic predispositions (such as Lynch syndrome).
The incidence of endometrial cancer is increasing worldwide, particularly in developed countries in Europe and North America. With changes in lifestyle, incidence rates in Asia are also rising. In Southeast Asian countries such as Thailand and Malaysia, the number of cases is growing year by year, raising public health concerns.
1. Invasion and Metastasis
Endometrial cancer is initially confined to the endometrium, but as the disease progresses, cancer cells may invade the myometrium and even spread to lymph nodes and distant organs, posing serious life-threatening risks.
2. Impact on Reproductive Function
This disease affects the female reproductive system, causing significant harm to fertility, especially in women of childbearing age. Advanced cases often require hysterectomy, leading to permanent infertility.
3. Decline in Quality of Life
Cancer-related pain, bleeding, and psychological stress severely affect patients' quality of life, and long-term treatment side effects further increase the physical burden.
4. Increased Treatment Difficulty
Endometrial cancers diagnosed at advanced stages are more difficult to treat and have a poor prognosis. Early detection and intervention are key to reducing mortality.
Immune reconstruction cell therapy works by regulating the patient's immune system, enhancing the body’s ability to fight cancer, and promoting the clearance of cancer cells. This therapy combines targeting ability with low toxicity, making it suitable for use alongside traditional therapies to improve overall treatment outcomes.
In clinical practice, cancer patients undergoing surgery, radiotherapy, and chemotherapy often face immune suppression, increased infection risk, and slow recovery. To help patients better tolerate treatments and improve survival quality, phased immune reconstruction plans tailored to different treatment cycles are necessary.
● Short-term plan: Rapidly enhance immunity through immune cell reinfusion, strengthening the effect of anti-cancer treatments.
● Mid-term plan: Reduce side effects of traditional therapies, promote recovery, and ensure treatment completion.
● Long-term plan: Comprehensive immune reconstruction, including immune cell, gut immune, elemental immune, and nutritional immune rebuilding, to improve overall immunity, quality of life, and survival.
1. Surgical Treatment
Surgery remains the primary treatment for endometrial cancer. Early-stage patients usually undergo total hysterectomy with bilateral salpingo-oophorectomy, yielding good outcomes. With advancements in minimally invasive techniques, laparoscopic and robot-assisted surgeries have become mainstream, offering less trauma and faster recovery.
2. Radiotherapy
Radiotherapy is commonly used as adjuvant therapy after surgery or for patients ineligible for surgery. It effectively controls local tumors and reduces recurrence risks. Modern precision radiotherapy techniques, such as IMRT, minimize damage to surrounding healthy tissues.
3. Chemotherapy
For advanced or metastatic patients, chemotherapy is often applied with various drug combinations to suppress cancer cell growth. Side effects must be properly managed, and comprehensive supportive care is indispensable.
4. Minimally Invasive Treatment
Laparoscopic and robotic surgeries, as minimally invasive techniques, help preserve normal tissues, reduce surgical trauma, shorten hospital stays, and accelerate recovery.
5. Endocrine Therapy
For hormone receptor-positive endometrial cancers, endocrine therapy slows tumor growth by inhibiting hormonal effects. This method is suitable for certain early-stage patients.
Endometrial cancer poses a serious threat to women’s health, making early diagnosis and standardized treatment extremely important. Immune reconstruction cell therapy, as an innovative approach, has greatly enriched treatment options. Experts at the United Life International Medical Center emphasize that patients should prioritize prevention and management, adopt multidisciplinary treatments, and focus on improving both survival rates and quality of life.