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Aplastic anemia is a disease caused by damage to bone marrow hematopoietic stem cells, manifested as bone marrow failure and peripheral blood cytopenia, leading to clinical symptoms such as anemia, infections, and bleeding. The etiology is complex and may be related to autoimmune abnormalities, drug exposure, or environmental factors, severely affecting patients’ quality of life and survival.
Europe and America
The incidence of aplastic anemia in Europe and America is about 2 to 3 cases per million annually. Causes are diverse, including drugs, radiation exposure, and immune factors. With advanced medical conditions, stem cell transplantation and immunosuppressive therapy are widely used, improving survival rates, but treatment challenges remain.
Southeast Asia
The incidence is relatively higher in Southeast Asia, about 4 to 6 cases per million annually. In some regions, environmental pollution and pesticide exposure have increased the incidence. With limited resources, treatment approaches are still developing, stem cell transplantation rates are low, and advanced therapeutic technologies are urgently needed.
Blood cell reduction significantly increases the risks of anemia, bleeding, and infections, seriously threatening patients’ lives. Chronic anemia affects tissue and organ oxygen supply, leading to multi-system dysfunction.
Immune deficiency caused by bone marrow failure makes patients prone to severe infections, which are difficult to treat, and some patients may progress to myelodysplastic syndrome or leukemia, increasing mortality.
Immune reconstruction cell therapy regulates and repairs patients’ damaged immune systems, promotes bone marrow hematopoietic function recovery, effectively relieves anemia symptoms, and reduces infection risks. This therapy not only improves immune tolerance but also enhances self-repair ability, significantly improving quality of life and therapeutic efficacy.
1. Strong immune regulation
This therapy precisely modulates abnormal immune responses, suppresses immune-mediated bone marrow damage, and promotes hematopoietic stem cell recovery.
2. Improved immune tolerance
By reconstructing normal immune function, it reduces immune rejection and inflammatory responses, improving treatment tolerance.
3. Long-term effectiveness
Scientific staged immune reconstruction continuously promotes hematopoietic recovery, reduces relapse rates, and improves survival quality.
In clinical practice, traditional therapies often face problems such as immune dysfunction, increased infection risks, and slow recovery. To better support patients, improve tolerance, and enhance survival quality, staged immune reconstruction plans should be scientifically designed for different treatment cycles.
● Short-term plan: Rapidly enhance immunity through immune cell reinfusion to strengthen therapeutic effectiveness.
● Mid-term plan: Reduce side effects of conventional therapies, promote recovery, and ensure completion of standardized regimens.
● Long-term plan: Improve immunity through immune cell reconstruction, gut immune reconstruction, elemental immune reconstruction, and immune nutrition reconstruction, enhancing quality of life and extending survival.
1. Bone marrow transplantation
Bone marrow or hematopoietic stem cell transplantation is a curative treatment, suitable for young patients with matched donors, but it carries risks of rejection and infection.
2. Immunosuppressive therapy
Drugs such as antithymocyte globulin and cyclosporine suppress abnormal immune responses and promote bone marrow function recovery.
3. Transfusion support
Red blood cell and platelet transfusions relieve anemia and bleeding symptoms, but long-term dependence may cause complications such as iron overload.
4. Growth factor therapy
Recombinant human erythropoietin and granulocyte colony-stimulating factor promote blood cell production and assist bone marrow function recovery.
5. Anti-infection therapy
Active prevention and treatment of infections with broad-spectrum antibiotics and antifungal drugs reduce infection-related complications.
6. Symptomatic treatment
Includes hemostasis, nutritional support, and cardiopulmonary function maintenance, improving overall condition and enhancing treatment effectiveness.
7. Traditional Chinese medicine adjunct therapy
Herbal medicine may regulate immunity and improve the hematopoietic microenvironment, serving as a supplementary treatment approach.
8. Psychological support
Attention to patients’ mental health reduces stress and promotes recovery.
Aplastic anemia is a life-threatening disease. Without timely treatment, it can cause multi-system damage or even death. Experts at United Life International Medical Center emphasize that scientific and reasonable treatment plans and early intervention are crucial. The application of immune reconstruction cell therapy brings new hope, with the potential to improve prognosis, enhance quality of life, and advance clinical treatment standards.
