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Melanoma is a malignant tumor formed by the abnormal proliferation of melanocytes in the skin and is the most serious form of skin cancer. It is the 5th most common cancer in both men and women in the United States. Its incidence increases with age. Although relatively uncommon, it is highly malignant and spreads rapidly to other parts of the body. Early detection and timely treatment are the keys to improving survival rates in patients.
The causes of melanoma are complex, including genetic factors, ultraviolet (UV) exposure, and weakened immune function. With environmental changes and lifestyle shifts, the number of melanoma patients worldwide continues to increase, making it an important global public health concern.
Melanoma has a high incidence in Europe and the United States, especially in Australia, New Zealand, and Northern Europe, closely related to strong local UV radiation. In recent years, incidence rates have also been rising in some Asian countries, such as Japan and South Korea. Southeast Asian countries have relatively low incidence rates, but due to large populations, the total number of cases cannot be ignored. With global warming and intensified UV radiation, the overall burden of melanoma worldwide will continue to rise.
In 2020, it was estimated that 325,000 new melanoma cases were diagnosed globally (174,000 men, 151,000 women), and about 57,000 people (32,000 men, 25,000 women) died from the disease. Among all newly diagnosed cases in 2020, 259,000 (79.7%) were over the age of 50. Among all deaths in 2020, 50,000 (87.7%) were over 50 years old.
1. Highly Malignant
Melanoma grows rapidly, is highly invasive, and easily penetrates the basal membrane of the skin, spreading to lymph nodes and distant organs, leading to multi-organ dysfunction.
2. Easy Metastasis
This disease easily spreads through the lymphatic system and bloodstream to vital organs such as the lungs, liver, and brain, increasing treatment difficulty and significantly reducing survival rates.
3. Diagnostic Challenges
Early melanoma symptoms are diverse and not obvious, often overlooked or misdiagnosed, resulting in delayed treatment and increased risk of death.
4. Complex Treatment
Due to its high heterogeneity and immune escape mechanisms, traditional surgery and chemotherapy have limited effectiveness, and patients often require comprehensive treatment strategies.
Immune reconstruction cell therapy activates and enhances the patient’s immune system to effectively identify and kill melanoma cells, significantly improving prognosis. This therapy boosts immune cell activity, reduces recurrence rates, and has relatively mild side effects, making it an important breakthrough in melanoma treatment.
In clinical practice, melanoma patients undergoing traditional treatments such as surgery, radiotherapy, and chemotherapy often face impaired immune function, increased infection risks, and slow recovery. To better support patients during the treatment process, improve tolerance, and enhance quality of life, scientifically tailored immune reconstruction plans are needed for different stages of treatment.
● Short-term plan: Rapidly enhance immunity through immune cell infusion, strengthening the effectiveness of anti-tumor treatment.
● Mid-term plan: Reduce side effects of traditional treatments, promote recovery, and ensure completion of standardized treatment courses.
● Long-term plan: Comprehensive enhancement of immunity through immune cell reconstruction, gut immune reconstruction, elemental immune reconstruction, and immune nutrition reconstruction, thereby improving quality of life and extending survival.
1. Surgical Resection
Surgery is the preferred treatment for early-stage melanoma. Removing the tumor and part of the surrounding normal tissue aims for a cure and shows significant effectiveness in localized disease.
2. Radiation Therapy
Radiation therapy can be used for local treatment of melanoma, especially after surgical resection, to eliminate residual cancer cells or prevent local recurrence. It can also be used for widespread metastases or palliative pain control.
3. Targeted Therapy
Targeted therapies aimed at specific gene mutations or abnormalities in melanoma can be applied. These drugs act on specific pathways in cancer cells to control or inhibit melanoma growth.
4. Chemotherapy
Chemotherapy is not commonly used for melanoma, as it generally responds poorly to traditional chemotherapeutic drugs. However, in advanced or metastatic melanoma, chemotherapy may still be an option.
Melanoma, due to its high malignancy and tendency to metastasize, poses a serious health threat. Early diagnosis and multimodal treatments are key to disease control. Experts at United Life International Medical Center point out that the introduction of immune reconstruction cell therapy provides patients with more effective and safer treatment options, significantly improving outcomes and deserving wider application. Timely treatment and scientific management are essential for improving survival rates.
