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Leukemia is a malignant tumor that affects the hematopoietic function of the bone marrow, originating from abnormally proliferating white blood cells. Normally, white blood cells are generated in the bone marrow and released into the blood to perform immune functions. In leukemia, abnormal cells replicate massively, suppressing the production of normal blood cells, leading to anemia, infections, bleeding, and a series of clinical problems. Based on disease progression and cell type, leukemia can be classified into acute lymphoblastic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia, and chronic myeloid leukemia. Early symptoms are not obvious, requiring tests such as blood routine and bone marrow aspiration for diagnosis. Treatment strategies must be individualized, covering various drug regimens and cell therapy approaches, aiming to eradicate malignant cells and restore bone marrow hematopoietic function.
The overall incidence of leukemia in Europe and the U.S. is slightly higher than in Asia. Acute lymphoblastic leukemia is more common in children, while chronic forms are often seen in middle-aged and elderly patients. In China, the disease shows a trend toward younger onset, with increasing treatment demand.
1. Immune system damage
Abnormal white blood cells occupy the bone marrow, inhibiting the production of normal immune cells, making patients highly susceptible to infections, with recurrent fevers and severe sepsis being common.
2. Anemia and bleeding tendency
The sharp reduction of normal red blood cells and platelets leads to fatigue, pallor, and symptoms such as gum bleeding, nosebleeds, or subcutaneous bruising.
3. Organ infiltration complications
Some types of leukemia may affect the liver, spleen, lymph nodes, or central nervous system, causing hepatosplenomegaly and neurological symptoms, with rapid disease progression.
4. Psychological and family pressure
Especially for families of pediatric patients, the long treatment cycle and high costs cause psychological trauma and financial burdens, requiring social support and continuous care.
Immune reconstruction cell therapy works by infusing active immune cells to clear residual leukemia cells in the body, while repairing immune deficiencies caused by chemotherapy or leukemia itself, thus achieving both treatment and recovery. This therapy provides significant support for long-term remission and relapse prevention, especially for relapsed or refractory leukemia patients, improving survival quality.
During actual treatment, cancer patients undergoing traditional therapies such as surgery, radiotherapy, and chemotherapy often face immune dysfunction, increased risk of infection, and slow recovery. To better support patients through treatment, improve tolerance, and enhance quality of life, phased immune reconstruction plans tailored to different treatment cycles should be scientifically developed.
● Short-term plan: Rapidly enhance immunity through immune cell reinfusion, boosting the effectiveness of anti-tumor treatment.
● Mid-term plan: Reduce side effects of traditional treatments, promote physical recovery, and complete standardized treatment courses.
● Long-term plan: Improve overall immunity through immune cell reconstruction, gut immune reconstruction, elemental immune reconstruction, and immune nutrition reconstruction, thereby enhancing quality of life and prolonging survival.
1. Chemotherapy and targeted therapy
Traditional chemotherapy remains the foundation of leukemia treatment, especially for acute types. For chronic leukemia, targeted drugs such as imatinib can address specific molecular mutations, improving treatment efficacy with relatively manageable side effects.
2. Bone marrow transplantation
Autologous or allogeneic hematopoietic stem cell transplantation is an important curative method for leukemia. By transplanting healthy hematopoietic cells, bone marrow function is reconstructed, making it suitable for high-risk or relapsed patients. Transplantation must be combined with immunosuppression and infection control measures.
3. Cellular immunotherapy
Cellular therapies such as CAR-T have made breakthroughs in specific types of leukemia, especially acute lymphoblastic leukemia in children. This therapy engineers T cells to precisely attack cancer cells, suitable for patients who fail multiple lines of treatment.
4. Comprehensive minimally invasive supportive therapy
Some treatments integrate minimally invasive techniques, such as central venous catheter-assisted chemotherapy and guided bone marrow aspiration, improving precision and comfort. At the same time, psychological intervention, nutritional support, and physical training improve the overall treatment experience.
Leukemia has an acute onset and far-reaching impacts, and without timely treatment, it can be life-threatening. Experts at United Life International Medical Center emphasize that precise treatment strategies and emerging therapies such as immune reconstruction cell therapy bring continued recovery and hope for leukemia patients.
